IRCT2012061710048N1 IRCT 2012-06-20 Babol University of Medical Sciences Comparison of the effects of cognitive behavioral therapy and pharmacotherapy on infertility stress Comparison of the effects of cognitive behavioral therapy and pharmacotherapy on infertility stress: A randomized controlled trial 2007-03-20 anticipated 89 Complete https://irct.ir/trial/10535 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. 2 Infertility stress. Intervention 1: Participants in the CBT group were engaged in a 10-week, two-hour group cognitive behavior therapy program. Progressive muscle relaxation was added to sessions 5–10. Groups consisted of 8–12 members and the therapist was an expert psychologist who trained for the CBT program. Therapy was conducted at the Psychiatry Department of the Babol University of Medical Sciences. The first three sessions provided patients with a general orientation to cognitive therapy and the causes of infertility. A gynecologist participated in the first three sessions for 30 minutes and explained the cause of infertility for each patient.Cognitive interventions have been based on the premise that both negative automatic thoughts and dysfunctional attitudes to social concerns, sexual concerns, marital concerns, rejection of childfree lifestyle, and need for parenthood more require restructure. The following three sessions (sessions 4–6) included the identification and challenging of core dysfunctional or irrational beliefs that underlie automatic negative thoughts about the infertility. Finally, sessions 7–10 taught participants varying techniques (e.g. countering, self-reward) for maintaining the change of their dysfunctional beliefs about infertility. In addition to the above program, sessions 5–10 taught participants progressive muscle relaxation in a group setting. For home practicing, subjects read a relaxation book and listened to a 20-minute pre-recorded CD two times daily over a period of 5 weeks. Cognitive sessions were conducted based on Beck Depression Inventory and tension releasing sessions were conducted based on Relaxation Inventory of Jacobson. Intervention 2: The pharmacotherapy group took a capsule of fluoxetine (20 mg) daily for 90 days. After the interview, the subjects took 30 capsules from the midwives of the center and return monthly to get their drug. Intervention 3: The control group didn’t undergo any drug or psychological intervention. They completed two questionnaires at the beginning of the study and 3 months after the interview.