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IRCT2012071810017N3 IRCT 2012-07-24 Tehran University of Medical Sciences effect of azithromycin on the prevention of wound infection Comparison of Cephalexin and Azithromycin regimen for infection prophylaxis in simple dirty wounds treated at emergency department. 2012-04-03 anticipated 400 Complete https://irct.ir/trial/10513 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A traumatic wounds management. Intervention 1: control:oral cephalexin 1000 mg befor wound manipulation and then 500 mg q 6 h for 3 days. Intervention 2: intervention:oral azithromycin 500 mg befor manipulation and then 250 mg daily for 3 days.
public Dr Abbas Edalatkhah
Satarkhan street, Niayesh street, Rasoul-akram hospital
Tehran Iran (Islamic Republic of) +98 21 6652 5327 abbas_edalatkhah@yahoo.com Tehran University of Medical Sciences, School of Medicine scientific Dr Hamed Basir Ghafouri
Satarkhan street, Niayesh sreet, Rasoul-Akram Hospital,Emergency Department
Tehran Iran (Islamic Republic of) +98 21 6652 5327 h-basirghafouri@tums.ac.ir Tehran University of Medical Science, School of Medicine Iran (Islamic Republic of) Inclusion criteria: presence of traumatic simple wounds with indication of antibiotic prophylaxis according to responsible physician’s opinion Exclusion criteria: presence of penetrating wound, longer than 12 hours, presence of diabetes, cirrhosis, or renal failure, current using of antibiotics or immunosuppressive agents, splenectomy, prosthetics heart valves, immunosuppressive disorders, fractures at the site of wound, bites, joint, neurovascular or tendon involvement 16 years 149 years Both T79.3 Post-traumatic wound infection, not elsewhere classified Treatment - Drugs Treatment - Drugs control:oral cephalexin 1000 mg befor wound manipulation and then 500 mg q 6 h for 3 days intervention:oral azithromycin 500 mg befor manipulation and then 250 mg daily for 3 days. Infection. Timepoint: 48 hr,240 hr. Method of measurement: presence of either a stitch abscess, cellulitis greater than 1 cm,or purulent drainage. Tehran University of Medical Sciences Approved 2012-03-29 Tehran Universty of Medical Sciences Ethics Committee Keshavarz Blvd, Qods St. Headquarter for Tehran University of Medical Sciences, Tehran Iran (Islamic Republic of)