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IRCT2012061110002N1 IRCT 2013-03-25 Research and Technology Teputy, Diabetes Research Center Effect of vitamin D supplementation on diabetes type 2 Effect of vitamin D supplementation on insulin resistance and glycemic control in patients with diabetes type 2 2013-03-05 anticipated 120 Complete https://irct.ir/trial/10498 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Diabetes type 2. Intervention 1: placebo group will recieve placebo capsul made of hard jellatinous material as the same method as intervention group. Intervention 2: Intervention group will recieve 50000 IU vitamin D3 every 2 weeks for 3 months orally.
public Dr.Homeyra Rashidi
Diabetes Research Center, Near the Information Center, Ahvaz Jondishapour Medical Sciences, University city, Ahvaz
Ahvaz Iran (Islamic Republic of) +98 61 1336 9539 hrashidi2002@yahoo.com Diabetes Research Center scientific Dr. Homeyra Rashidi
Ahvaz, Azadegan street, Imam Khomeini hospital
Ahvaz Iran (Islamic Republic of) 00986112222086, 00986112220118 hrashidi2002@yahoo.com Diabetes Research Center Iran (Islamic Republic of) inclusion critera : 1) patients with diabetes type 2 according to ADA criteria 2011 and under treatment with oral hypoglycemic agents, 2) HbA1C ≤ 8.5%, 3) patients with 21-60 of age, 4) BMI>20 exclusion criteria : 1) end stage diseases of organs such as ESRD,chronic liver disease 2)GFR≤30ml/min, 3) hypercalcemia and kidney stones,4) known primary hyperparathyroidism,5) heart diseases included ischemic heart disease, heart failure,cardiomyopathy,6) sarcoidosis,7) TB ,8) cancer,9) history of IBD ,10) pregnancy,11) SBP/SDP≥175/104 mmHg ,12) consumption of vitamin D supplement over 400 IU within 2 months prior to intervention 21 years 60 years Both E-11 Non-insulin-dependent diabetes mellitus Treatment - Drugs Treatment - Drugs placebo group will recieve placebo capsul made of hard jellatinous material as the same method as intervention group. Intervention group will recieve 50000 IU vitamin D3 every 2 weeks for 3 months orally. Insulin resistance and glycemic control (glucose*insulin/405). Timepoint: just before and after 3 months of intervention. Method of measurement: alisun 3000 measure system. HOMA-Beta. Timepoint: just before after 3 months of intervention. Method of measurement: glucose* insulin /405. Hb A1C. Timepoint: just before after 3 months of intervention. Method of measurement: high performance liquid chromatography method using G8 TOSO Ssystem. HOMA - IR. Timepoint: just before and 3 months after intervension. Method of measurement: insulin* 360 / glucose -63 %. Determination and comparison of the distribution of vitamin D (25 (OH) D) levels before and after treatment in both intervention and control groups. Timepoint: just before and after 3 months of intervention. Method of measurement: Chemiluminescence method using liusun system. Research and Technology Teputy, Diabetes Research Center Approved 2013-02-17 Research and Technology Deputy, Research Ethics Committee Ahvaz University City, Department of Research and Technology, Ahvaz Jundishapur University of Medical Sciences and Health Services Ahvaz Iran (Islamic Republic of)