IRCT201206069957N1 IRCT 2013-01-29 Vice chancellor for Research and Technology, Zahedan University of Medical Sciences The effect of Aloe vera gel on menstrual pain Evaluation the effect of oral Aloe vera gel on severity of primary dysmenorrhea in students of Zahedan University of Medical Sciences 2011-12-22 anticipated 80 Complete https://irct.ir/trial/10469 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Dysmenorrhea. Intervention 1: The Aloe vera group took 1 tablespoon Aloe vera gel by oral three times per day from two days before and three days after the beginning of menstrual cycle for two consecutive cycles. Intervention 2: The placebo group took 1 tablespoon placebo gel by oral three times per day from two days before and three days after the beginning of menstrual cycle for two consecutive cycles.

public Mahdiye Donyadari

School of Nursing and Midwifery, Mashahir Sq

Zahedan Iran (Islamic Republic of) 9819613396 +98 54 1243 8473 m_20282000@yahoo.com Zahedan University of Medical Sciences scientific Shahin_ Dokht Navvabi Rigi

School of Nursing and Midwifery, Mashahir Sq

Zahedan Iran (Islamic Republic of) +98 54 1341 6706 shahinnavabi@yahoo.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: being unmarried, having score 4 to 10 for dysmenorrhea according to pain scale, not known chronic diseases, having regular menstrual periods between 21 to 35 days, no history of myoma, pelvic tumor, andometriosis and pelvic inflammatory disease, no taking oral particular drug, no history of allergy to herbal drugs. Exclusion criteria: allergy to Aloe vera during intervention, incorrect taking the drug. 18 years 25 years Female N94.4 Primary dysmenorrhea Treatment - Drugs Placebo The Aloe vera group took 1 tablespoon Aloe vera gel by oral three times per day from two days before and three days after the beginning of menstrual cycle for two consecutive cycles. The placebo group took 1 tablespoon placebo gel by oral three times per day from two days before and three days after the beginning of menstrual cycle for two consecutive cycles. Severity of primary dysmenorrhea. Timepoint: 3 menstrual cycles, one cycle before the study and 2 cycles during the study with 5 time intervals: first 2 hours from onset of menses, 2 to 12 hours, 12 to 24 hours, second day and third day of menstrual cycle. Method of measurement: verbal multidimensional scoring system and visual analogue scale. Nausea. Timepoint: during first 3 days of the menstrual period and at the end of the menstrual period for 2 cycles of intervention. Method of measurement: Questionnaire (Yes, No). Vomiting. Timepoint: during first 3 days of the menstrual period and at the end of the menstrual period for 2 cycles of intervention. Method of measurement: Questionnaire (Yes, No). Diarrhea. Timepoint: during first 3 days of the menstrual period and at the end of the menstrual period for 2 cycles of intervention. Method of measurement: Questionnaire (Yes, No). Headache. Timepoint: during first 3 days of the menstrual period and at the end of the menstrual period for 2 cycles of intervention. Method of measurement: Questionnaire (Yes, No). Itching. Timepoint: during first 3 days of the menstrual period and at the end of the menstrual period for 2 cycles of intervention. Method of measurement: Questionnaire (Yes, No). Hives. Timepoint: during first 3 days of the menstrual period and at the end of the menstrual period for 2 cycles of intervention. Method of measurement: Questionnaire (Yes, No). Vice chancellor for Research and Technology, Zahedan University of Medical Sciences Approved 2011-12-08 Research Ethics committee of Zahedan University of Medical Sciences Pardis University of Medical Sciences Campus, Hessabi Sq Zahedan Iran (Islamic Republic of)