IRCT201205309910N1 IRCT 2012-06-24 Isfahan University of Medical Sciences Comparing two different drug methods for infertility treatment by assisted reproduction techniques (ARTs) GnRH Investigation of outcome of assessment reproduction treatment and prevention of ovarian hyper stimulation syndrome in GnRH agonist protocol compared to GnRH antagonist protocol 2011-01-22 anticipated 136 Complete https://irct.ir/trial/10434 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 infertility. Intervention 1: Group A: a daily dose of Buserelin 500 µg given SC and commenced 21th day of cycle, and vaginal ultrasonography continued onward until estradiol on the 2nd day of cycle. Intervention 2: Group B: GnRH antagonist was administered. Ovarian stimulation was started on the 2nd day of the cycle by SC injection of 75 IU of FSH daily. On the 6th day of stimulation, 0.25 mg Cetrorelix was initiated. Based on the ovarian response detected by ultrasonography, gonadotropin dose was adjusted in both groups. Administration of Buserelin and Cetrorelix was continued until the time of HCG injection. When at least 3 follicles with a mean diameter of 18 mm were developed, HCG 10,000 IU was injected IM. At this stage, endometrial thickness was studied Trans vaginal ultrasonographically, and after 36 hours, oocyte retrieval was performed. After IVF or ICSI, Cyclogest 800 mg was prescribed daily to provide luteal phase support and continued till the activity of FHR was confirmed TVS.16days after the oocyte retrieval, serum HCG level was checked to determine chemical pregnancy. TVS was carried out for clinical determination of pregnancy.