IRCT201208159585N2 IRCT 2013-02-07 Vice Chancellor for research of Kerman University of Medical Sciences Assessment of therapeutic effects of Ketamin in treatment of major depression • Anti depressant effect of Ketamin versus Thiopental Na for ECT in major depression disorder patients 2012-09-22 anticipated 60 Complete https://irct.ir/trial/10159 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: This is a double blind clinical trial on 60 patients who undergo Electroconvulsive therapy (ECT). All the patients will sign informed consent but they are blind to the administered medicine. The patients will be divided into two groups of 30 ones by means of random numbers table. A resident of anesthesiology injects the medicine; however the anesthesia technician who controls and records the vital signs and severity of convulsion, and the psychologist who evaluates the patient are unaware of the medication. 2-3 Condition 1: major depression. Condition 2: Major depression. Intervention 1: Intervention: Ketamin (50 mg per ml, made by ROTEXMEDICA/Germany) 0.5_1mg/kg, administering stat and IV. Intervention 2: Control: Thiopental Na (50 mg per ml, made by Nani Pharmaceuticals Pvt.Ltd) 3 mg/kg, administering stat and IV.