]>
IRCT201403109472N6 IRCT 2014-03-19 Vice-chancellor for Research, Iran University of Medical Sciences The effect of Ginger powder consumption on some genes expression that are mediators of immunity and inflammation in adult with Rheumatoid Arthritis The effect of Ginger supplementation consumption on some genes expression that are mediators of immunity and inflammation in adult with active Rheumatoid Arthritis 2014-03-11 anticipated 70 Complete https://irct.ir/trial/10053 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. N/A adult active Rheumatoid arthritis. Intervention 1: Intervention Group: Patients that refer to hospital shariatti have interval criteria and will receive Ginger voluntarily. Patients in case group will receive 1500 mg of powdered Ginger daily (by two 750 mg capsules) for 3 months ne 750 mg capsule before lunch and one before dinner for 3 months. Intervention 2: Control groups: Patients that refer to hospital shariatti have interval criteria and will receive starch or flour voluntarily. Patients in Control group will receive 1500 mg of wheat flour daily (by two 750 mg capsules) one 750 mg capsule before lunch and one before dinner for 3 months.
public Naheed Aryaeian
Nutrition faculty, School of public health, Iran University of Medical Sciences, Hammat Broad way
Tehran Iran (Islamic Republic of) 1449614535 +98 21 8670 4755 nah_arya2002@yahoo.comaryaeian.n@iums.ac.iraryaeian@razi.tums.ac.ir Iran University of Medical Sciences scientific Naheed Aryaeian
Nutrition faculty, School of public health, Iran University of Medical Sciences, Hammat Broad way
Tehran Iran (Islamic Republic of) +98 21 8670 4755 aryaeian.n@iums.ac.ir nah_arya2002@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: person with RA diseases as ACR criteria, having RA from 2 years ago; age between 18-69 years; not being pregnant or lactated; not smoking and drink alcohol; haven’t eaten multivitamin or antioxidants supplements from 3 month ago; don't eat lowering blood pressure; don't eat anti pregnancy drugs, exclusion criteria: Changes in diet or physical activity every day; taking less than 80% of supplements given to patients at baseline(the compliance lower than %80); consumption of contraceptives, multivitamins and antioxidant supplements; renal , hepatic , thyroid, parathyroid diseases, cancer, heart diseases 18 years 69 years Both M06.9 Rheumatoid arthritis, unspecified Treatment - Drugs Placebo Intervention Group: Patients that refer to hospital shariatti have interval criteria and will receive Ginger voluntarily. Patients in case group will receive 1500 mg of powdered Ginger daily (by two 750 mg capsules) for 3 months ne 750 mg capsule before lunch and one before dinner for 3 months. Control groups: Patients that refer to hospital shariatti have interval criteria and will receive starch or flour voluntarily. Patients in Control group will receive 1500 mg of wheat flour daily (by two 750 mg capsules) one 750 mg capsule before lunch and one before dinner for 3 months. NFkB Jene expression amount. Timepoint: Before and after study. Method of measurement: PCR. PPARγ Jene expression amount. Timepoint: Before and after study. Method of measurement: PCR. Foxp3 Jene expression amount. Timepoint: Before and after study. Method of measurement: PCR. GATA3 Jene expression amount. Timepoint: Before and after study. Method of measurement: PCR. T-bet Jene expression amount. Timepoint: Before and after study. Method of measurement: PCR. RORγ Jene expression amount. Timepoint: Before and after the study. Method of measurement: PCR. BMI. Timepoint: Before and after study. Method of measurement: Formula. Vice-chancellor for Research, Iran University of Medical Sciences Approved 2014-03-05 Vice-chancellor for Research, Iran University of Medical Sciences Hemmat Broadway Tehran Iran (Islamic Republic of)